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Resveratrol Antioxidants and Weight Loss: A Good Pairing?The golden rule in weight loss is pretty simple: take in fewer calories than you expend in exercise. However, as any dieter will tell you, it’s far from easy. Americans spend billions of dollars a year on weight loss supplements, exercise programs and other diet aids—and still we can’t seem to win the battle of the bulge—even when we get desperate enough to try risky surgery or fad diets.Recently a new product has come to light that may help people trying to lose weight stay on the healthy end of the spectrum: Resveratrol Select, which is unlike many diet supplements in that it uses a combination of natural and herbal ingredients designed to help the body stay healthy while losing weight.How? By mimicking certain aspects of the Mediterranean diet.Studies have shown that part of America’s war with weight lies in the uniquely modern American combination of stressful lifestyle and fast-food consumption, and that the Mediterranean diet and lifestyle seem to be more conducive to healthier weight levels and longevity. In fact, much as been made on the news in recent months of the purported “French Paradox,” (how the French eat a high-fat diet, enjoy rich desserts, drink wine and still have better cardiovascular health than the rest of us). One of the biggest differences between the American and French diet seems to be the wine consumption, and red wine (a staple on most Mediterranean tables) contains one of nature’s most powerful antioxidants, resveratrol, which is a key ingredient in Resveratrol Select.In addition to wine, resveratrol is also found in grape skins, blueberries, cranberries and other plants, and recent animal and in vitro studies indicate that it can have a positive effect on helping to maintain healthy cholesterol levels, supporting insulin health and optimizing metabolic and immune pathways that protect cells and improve mitochondrial function. * And one capsule of Resveratrol Select includes as much resveratrol as 200 glasses of wine—without the added calories that alcohol can add to the waistline.But consuming resveratrol alone isn’t enough to help with weight loss—so the manufacturers of Resveratrol Select also added a different type of antioxidant, Green Tea Extract (EGCG), which could make a big difference. Over time, green tea consumption helps increase metabolism, burn fat and reduce fat storage due to its caffeine and L-theanin content, which can be pivotal in helping to maintain energy for exercise. *Resveratrol Select combines these two powerful antioxidants with yet another energy boosting ingredient, Chromium, a niacin-based mineral that plays an important role in how the body uses insulin to burn sugars, carbohydrates, fats, and proteins for energy.*Although relatively new to the market, Resveratrol Select seems to be making a big splash, and many people are taking advantage of the free trial offer to see how well the product works for them. The trial offer also includes two bonus tools to help with weight loss: an e-book with over 70 weight loss tips, and a weight loss visualization audio.Of course, consuming fewer calories while burning more is the most efficient form of weight loss, and it’s always a good idea to inform your doctor before taking a weight loss supplement, but this new combination herbal supplement is worth a look for those concerned about maintaining good health while losing weight. For more information on Resveratrol Select’s free trial offer and bonus materials, visit http://www.resveratrolselect.com.

Antioxidant levels key to prostate cancer risk in some men

Greater levels of selenium, vitamin E and the tomato carotenoid lycopene have been shown to reduce prostate cancer in one out of every four Caucasian males, or those who inherit a specific genetic variation that is particularly sensitive to oxidative stress, say US researchers.

Conversely, if carriers of this genetic variant have low levels of these vitamins and minerals, their risk of aggressive prostate increases substantially, as great as 10-fold, over those who maintain higher levels of these nutrients, they write in today’s issue of Cancer Research.

"This large prospective study provides further evidence that oxidative stress may be one of the important mechanisms for prostate cancer development and progression, and adequate intake of antioxidants, such as selenium, lycopene and vitamin E, may help prevent prostate cancer," said Dr Haojie Li, a researcher at the Brigham and Women's Hospital and Harvard Medical School.

The new findings are based on an analysis of 567 men diagnosed with prostate cancer between 1982 and 1995, and 764 cancer-free men from the Physicians Health Study.

The initial goal of this study was to assess the effect of aspirin and beta-carotene on men's health. Li’s team decided to check for variants of the gene that codes for manganese superoxide dismutatase (MnSOD), an important enzyme that works as an antioxidant in human cells to defend against disease.

The MnSOD gene is passed from parents to offspring in one of three forms: VV, VA or AA.

"Compared with men with the MnSOD VV or VA genotype, people with the AA genotype seem to be more sensitive to the antioxidant status," said Li. "Men with the AA genotype are more susceptible to prostate cancer if their antioxidant levels are low."

The study's results found that a quarter of the men in the study carried the MnSOD AA genotype, half carried the VA genotype, and the remaining quarter carried the VV genotype.

The results indicated that the VA and VV men were at equivalent risk for developing prostate cancer across all levels of antioxidants in their blood.

But compared to MnSOD VV or VA carriers in the lowest quartile of selenium levels, MnSOD AA males had an 89 per cent greater risk for developing aggressive prostate cancer if they had low blood levels of the mineral.

On the other hand, MnSOD AA carriers with high selenium – those men in the highest quartile – had a 65 per cent lower risk than the MnSOD VV or VA males who maintained low levels of selenium.

"The levels of selenium in the highest quartile of these men are not abnormally high," Li said. "Our range is neither extremely high nor extremely low."

While similar trends were observed for lycopene and vitamin E when tested independently, the contrast in relative risk was most pronounced for the men who had high blood levels for all three antioxidants combined, said the researchers.

"Among men with the MnSOD AA genotype, we observed a 10-fold difference in risk for aggressive prostate cancer, when comparing men with high versus low levels of antioxidants combined,"said Li. "In contrast, among men with the VV or VA genotype, the prostate cancer risk was only weakly altered by these antioxidant levels."

"Our study, as well as many other epidemiological studies, encourages dietary intake of nutrients such as lycopene from tomato products, or supplements for vitamin E and selenium to reduce risk of prostate cancer," said Li.

Prostate cancer is one of the biggest cancer killers in industrial countries and affects more than 500,000 men worldwide every year. This number is expected to increase with the ageing population.

Similar interactions between dietary antioxidants and the variations in the MnSOD gene have previously been linked to risk for breast cancer.

For more information visit: http://www.prostacet.com